EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated April 26, 2006 (except Notes 5 and 6, as to which the date is July 20, 2006) in the Registration Statement (Form S-1, No. 333-           ) and the related Prospectus of Sourcefire, Inc. dated October 25, 2006 for the registration of shares of its common stock.

/s/ Ernst & Young LLP

Baltimore, Maryland
October 23, 2006