X0202 4 2005-05-24 1 0000946486 DISCOVERY LABORATORIES INC /DE/ DSCO 0001168060 NIVEN RALPH DISCOVERY LABORATORIES INC 2600 KELLY ROAD SUITE 100 WARRINGTON PA 18976 0 1 0 0 SVP- Preclinical Dev-Former Common Stock 2005-05-24 4 M 0 12217 3.09 A 100482 D Common Stock 2005-05-24 4 S 0 217 6.7079 D 100265 D Common Stock 2005-05-24 4 S 0 1000 6.6942 D 99265 D Common Stock 2005-05-24 4 S 0 1000 6.678 D 98265 D Common Stock 2005-05-24 4 S 0 1000 6.675 D 97265 D Common Stock 2005-05-24 4 S 0 1000 6.63 D 96265 D Common Stock 2005-05-24 4 S 0 1000 6.5738 D 95265 D Common Stock 2005-05-24 4 S 0 1000 6.571 D 94265 D Common Stock 2005-05-24 4 S 0 1000 6.563 D 93265 D Common Stock 2005-05-24 4 S 0 1000 6.562 D 92265 D Common Stock 2005-05-24 4 S 0 1000 6.554 D 91265 D Common Stock 2005-05-24 4 S 0 3000 6.55 D 88265 D Common Stock 2005-05-25 4 M 0 10000 4.44 A 98265 D Common Stock 2005-05-25 4 S 0 1000 6.745 D 97265 D Common Stock 2005-05-25 4 S 0 1000 6.745 D 96265 D Common Stock 2005-05-25 4 S 0 1000 6.7369 D 95265 D Common Stock 2005-05-25 4 S 0 1000 6.7624 D 94265 D Common Stock 2005-05-25 4 S 0 1000 6.766 D 93265 D Common Stock 2005-05-25 4 S 0 1000 6.764 D 92265 D Common Stock 2005-05-25 4 S 0 1000 6.774 D 91265 D Common Stock 2005-05-25 4 S 0 1000 6.802 D 90265 D Common Stock 2005-05-25 4 S 0 1000 6.836 D 89265 D Common Stock 2005-05-25 4 S 0 1000 6.846 D 88265 D Incentive Stock Option (right to buy) 3.09 2005-05-24 4 M 0 12217 0 D 2001-12-03 2011-12-03 Common Stock 12217 12000 D Incentive Stock Option (right to buy) 4.44 2005-05-25 4 M 0 10000 0 D 2001-02-22 2011-02-22 Common Stock 10000 10000 D Ralph Niven 2005-05-25