X0202 3 2007-05-24 0 0001274563 HELICOS BIOSCIENCES CORP HLCS 0001166721 LAPIDUS STANLEY N C/O HELICOS BIOSCIENCES CORPORATION 1 KENDALL SQUARE, BUILDING 700 CAMBRIDGE MA 02139 1 1 0 0 President and CEO Common Stock 444444 D Stock Option (Right to Buy) 1.80 2016-03-01 Common Stock 355555 D Series A Redeemable Convertible Preferred Stock Common Stock 23256 D Series B Redeemable Convertible Preferred Stock Common Stock 25839 D Of such shares, 400,000 shares represent restricted stock with restrictions lapsing 25% on the first anniversary of November 17, 2003 and 2.0833333% each month thereafter. 200,000 of such shares are held by Mr. Lapidus's wife. This option becomes exercisable at the rate of 25% on first anniversary of March 1, 2006 the date listed, with the balance becoming exercisable at the rate of 2.0833333% each month thereafter. The preferred stock is convertible at any time, at the holder's election, on a 4.5-for-one basis and has no expiration date. The preferred stock will automtaically convert upon the closing of the issuer's initial public offering, on a 4.5-for-one basis. /s/ Mark C. Solakian, attorney-in-fact 2007-05-24