LIMITED POWER OF ATTORNEY
                                     FOR
                       HELICOS BIOSCIENCES CORPORATION
                            SECTION 16(a) FILINGS

Know all by these presents, that the undersigned hereby constitutes and appoints
each of Mark C. Solakian and Louise A. Mawhinney, signing singly, the
undersigned's true and lawful attorney-in-fact to:

	(1)	Execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer, director and/or stockholder of Helicos
Biosciences Corporation (the "Company"), Forms 3, 4, and 5 and amendments
thereto in accordance with Section 16(a) of the Securities Exchange Act of 1934
and the rules thereunder;

	(2)	Do and perform any and all acts for and on behalf of the
undersigned which may be necessary or desirable to complete and execute any
such Form 3, 4, or 5 or amendment thereto and timely file such form with the
United States Securities and Exchange Commission (the "SEC") and any stock
exchange or similar authority; and

	(3)	Take any other action of any type whatsoever which, in the
opinion of such attorney-in-fact, may be necessary or desirable in connection
with the foregoing authority, it being understood that the documents executed
by such attorney-in-fact on behalf of the undersigned pursuant to this Power of
Attorney shall be in such form and shall contain such terms and conditions as
such attorney-in-fact may approve.

	The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform any and every act and thing whatsoever
required, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall
lawfully do or cause to be done by virtue of this Power of Attorney and the
rights and powers herein granted.  The undersigned acknowledges that the
foregoing attorneys-in-fact, in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company assuming, any of the
undersigned's responsibilities to comply  with Section 16 of the Securities
Exchange Act of 1934.

	This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file Forms 3, 4, and 5 with respect
to the undersigned's holdings of and transaction in securities of the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.  This Power of Attorney may be filed with the SEC
as a confirming statement of the authority granted herein.

                 [Remainder intentionally left blank]


IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this 27th day of April, 2007.




/s/ Stanley N. Lapidus
Stanley N. Lapidus