X0306 4 2021-03-30 0 0001346830 Cara Therapeutics, Inc. CARA 0001166287 CHALMERS DEREK T C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA, 107 ELM ST, 9TH FLOOR STAMFORD CT 06902 1 1 0 0 President & CEO Common Stock 2021-03-30 4 A 0 52000 0.00 A 1002511 D Employee Stock Option (Right to Buy) 20.59 2021-03-30 4 A 0 103000 0.00 A 2031-03-30 Common Stock 103000 103000 D Represents the number of shares underlying restricted stock units ("RSUs"). Each RSU represents the contingent right to receive one share of common stock of the Issuer. The RSUs vest in three equal annual installments on each of March 30, 2022, March 30, 2023 and March 30, 2024, in each case, subject to the Reporting Person's continued service (as that term is defined in the Issuer's 2014 Equity Incentive Plan) as of each such date. The shares shall vest and become exercisable in a series of 48 successive equal monthly installments beginning on April 30, 2021, in each case subject to the Reporting Person's continued service as of each such date. /s/Darren DeStefano, Attorney-in-Fact 2021-04-01