X0306 4 2018-12-27 0 0001346830 Cara Therapeutics, Inc. CARA 0001166287 CHALMERS DEREK T C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA, 107 ELM ST, 9TH FLOOR STAMFORD CT 06902 1 1 0 0 President & CEO Common Stock 2018-12-27 4 A 0 38221 0.00 A 1009613 D Represents the vesting in full of a performance-based restricted stock unit award based on the Issuer's satisfaction of certain performance criteria. In light of the performance-based vesting conditions of the award, such award was not reportable under Section 16 until vesting was determined, which occurred on December 27, 2018. Each restricted stock unit represented the contingent right to receive one share of common stock of the Issuer. /s/Darren DeStefano, Attorney-in-Fact 2018-12-31