<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001164255</cik>
        <entityName>INTERFACE SECURITY SYSTEMS HOLDINGS INC</entityName>
        <issuerAddress>
            <street1>3773 CORPORATE CENTER DRIVE</street1>
            <city>EARTH CITY</city>
            <stateOrCountry>MO</stateOrCountry>
            <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
            <zipCode>63045</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>314-595-0103</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <issuerList>
        <issuer>
            <cik>0001491898</cik>
            <entityName>Interface Security Systems, L.L.C.</entityName>
            <issuerAddress>
                <street1>3773 CORPORATE CENTER DRIVE</street1>
                <city>EARTH CITY</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </issuerAddress>
            <issuerPhoneNumber>314-595-0103</issuerPhoneNumber>
            <jurisdictionOfInc>LOUISIANA</jurisdictionOfInc>
            <issuerPreviousNameList>
                <value>None</value>
            </issuerPreviousNameList>
            <edgarPreviousNameList>
                <value>None</value>
            </edgarPreviousNameList>
            <entityType>Limited Liability Company</entityType>
            <yearOfInc>
                <overFiveYears>true</overFiveYears>
            </yearOfInc>
        </issuer>
        <issuer>
            <cik>0001491899</cik>
            <entityName>Greater Alarm Company, Inc.</entityName>
            <issuerAddress>
                <street1>3773 CORPORATE CENTER DRIVE</street1>
                <city>EARTH CITY</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </issuerAddress>
            <issuerPhoneNumber>314-595-0103</issuerPhoneNumber>
            <jurisdictionOfInc>CALIFORNIA</jurisdictionOfInc>
            <issuerPreviousNameList>
                <value>None</value>
            </issuerPreviousNameList>
            <edgarPreviousNameList>
                <value>None</value>
            </edgarPreviousNameList>
            <entityType>Corporation</entityType>
            <yearOfInc>
                <overFiveYears>true</overFiveYears>
            </yearOfInc>
        </issuer>
    </issuerList>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kenneth</firstName>
                <lastName>Obermeyer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer, Treasurer of Interface Security Systems Holdings, Inc.; Chief Financial Officer of Interface Security Systems, L.L.C.; Chief Financial Officer, Treasurer of The Greater Alarm Company, Inc.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>T.</middleName>
                <lastName>Shaw</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer, Secretary, Director of Interface Security Systems Holdings, Inc.; Chief Executive Officer, Secretary, Manager of Interface Security Systems, L.L.C.; Chief Executive Officer, Secretary, Director of the Greater Alarm Company, Inc.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Craig</firstName>
                <lastName>Jennings</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chairman of the Board, Director of Interface Security Systems Holdings, Inc.; Manager of Interface Security Systems, L.L.C.;
Director of The Greater Alarm Company, Inc.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <lastName>Boyle</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director of Interface Security Systems Holdings, Inc.;
Manager of Interface Security Systems, L.L.C.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Aranda</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director of Interface Security Systems Holdings, Inc.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>J.</middleName>
                <lastName>McLeod</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>President, Chief Operating Officer of Interface Security Systems Holdings, Inc.; President, Chief Operating Officer of Interface Security Systems, L.L.C.; President, Chief Operating Officer of The Greater Alarm Company, Inc.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Seay</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3773 Corporate Center Drive</street1>
                <city>Earth City</city>
                <stateOrCountry>MO</stateOrCountry>
                <stateOrCountryDescription>MISSOURI</stateOrCountryDescription>
                <zipCode>63045</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director of The Greater Alarm Company, Inc.</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Business Services</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-05-05</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isDebtType>true</isDebtType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>24000000</totalOfferingAmount>
            <totalAmountSold>24000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Issuer Interface Security Systems Holdings, Inc. issued $4,000,000 equity securities.
Issuer Interface Security Systems, L.L.C. and The Greater Alarm Company, Inc. issued $20,000,000 debt securities.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>The proceeds of sale will be used to refinance indebtedness of Interface Security Systems, L.L.C. and The Greater Alarm Company, Inc. and to pay related fees, costs and expenses.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>true</authorizedRepresentative>
            <signature>
                <issuerName>INTERFACE SECURITY SYSTEMS HOLDINGS INC</issuerName>
                <signatureName>Kenneth Obermeyer</signatureName>
                <nameOfSigner>Kenneth Obermeyer</nameOfSigner>
                <signatureTitle>Chief Financial Offier, Treasurer</signatureTitle>
                <signatureDate>2010-05-19</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
