<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001163949</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001374310</issuerCik>
      <issuerName>Cboe Global Markets, Inc.</issuerName>
      <secFileNumber>001-34774</secFileNumber>
      <issuerAddress>
        <com:street1>433 WEST VAN BUREN STREET</com:street1>
        <com:city>CHICAGO</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60607</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>312 786 7200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RATTERMAN JOSEPH P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 summer street</com:street1>
          <com:city>boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15000</noOfUnitsSold>
      <aggregateMarketValue>2052500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>105574464</noOfUnitsOutstanding>
      <approxSaleDate>05/24/2023</approxSaleDate>
      <securitiesExchangeName>Other</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>shares being sold from JOSEPH &amp; SANDRA RATTERMAN TRUST</remarks>
    <noticeSignature>
      <noticeDate>05/24/2023</noticeDate>
      <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Ratterman</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
