X0306 4 2018-04-23 0000922247 CTD HOLDINGS INC CTDH 0001163556 FINE N SCOTT 6714 NW 16TH STREET, SUITE B GAINESVILLE FL 32163 1 1 Chief Executive Officer Series B Convertible Preferred Stock 0.25 2018-04-23 4 P 0 1000 A Common Stock 400000 2000 D Warrant to Purchase Common Stock 0.25 2018-04-23 4 P 0 400000 A 2018-04-23 2025-04-23 Common Stock 400000 400000 D The Series B Convertible Preferred Stock ("Series B Preferred") will automatically convert into Common Stock on the date the Issuer effects an increase of its authorized shares of Common Stock and/or a reverse stock split so that it has a sufficient number of authorized and unissued shares of Common Stock to permit the conversion or exercise, as applicable of all outstanding shares of Series B Preferred, warrants, options and other convertible securities of the Issuer. The reported securities consist of 1,000 "Units" purchased by the reporting person for $100 per Unit. Each Unit consists of one share of Series B Preferred and warrants to purchase 400 shares of Common Stock. Includes 1,000 shares of Series B Preferred held by the pension plan of a limited liability company of which the reporting person is the sole member. /s/ N. Scott Fine 2018-04-24