X0306 4 2018-08-14 0 0000926617 VERMILLION, INC. VRML 0001162956 LAFRANCE JAMES T C/O VERMILLION, INC. 12117 BEE CAVES RD, BLDG 3 STE 100 AUSTIN TX 78738 1 0 0 0 Common Stock 2018-08-14 4 S 0 2573 0.51 D 318845 D Common Stock 2018-08-15 4 S 0 10427 0.49 D 301418 D Common Stock 2018-08-17 4 S 0 7500 0.51 D 300918 D Common Stock 2018-08-20 4 S 0 2900 0.54 D 298018 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The sale reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $0.5150 to $0.5156 per share. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The sale reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $0.4710 to $0.5150 per share. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The sale reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $0.5059 to $0.5150 per share. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. The sale reported in column 4 is a weighted average price. The shares were sold in multiple transactions at $0.5375 per share. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. /s/ James T. LaFrance 2018-08-21