<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-04-13</periodOfReport>

    <notSubjectToSection16>true</notSubjectToSection16>

    <issuer>
        <issuerCik>0001484612</issuerCik>
        <issuerName>Outset Medical, Inc.</issuerName>
        <issuerTradingSymbol>OM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001162870</rptOwnerCik>
            <rptOwnerName>WARBURG PINCUS LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WARBURG PINCUS LLC</rptOwnerStreet1>
            <rptOwnerStreet2>450 LEXINGTON AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2021-04-13</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>120612</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>50.825</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>26086</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2021-04-13</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3770111</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>50.825</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>815394</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These securities are held directly by Warburg Pincus X Partners, L.P., a Delaware limited partnership (&quot;WP X Partners&quot;).</footnote>
        <footnote id="F2">These securities are held directly by WP X Finance, L.P., a Delaware limited partnership (&quot;WP X Finance&quot;, and together with WP X Partners, the &quot;WPP Funds&quot;). WPX GP, L.P., a Delaware limited partnership (&quot;WPX GP&quot;), is the managing general partner of WP X Finance. Warburg Pincus Private Equity X, L.P., a Delaware limited partnership (&quot;WP X&quot;), is the general partner of WPX GP.</footnote>
        <footnote id="F3">Warburg Pincus X, L.P., a Delaware limited partnership (&quot;WP X LP&quot;), is the general partner of WP X and WP X Partners. Warburg Pincus X GP L.P., a Delaware limited partnership (&quot;WP X GP&quot;), is the general partner of WP X LP. WPP GP LLC, a Delaware limited liability company (&quot;WPP GP&quot;), is the general partner of WP X GP. Warburg Pincus Partners, L.P., a Delaware limited partnership (&quot;WP Partners&quot;), is the managing member of WPP GP. Warburg Pincus Partners GP LLC, a Delaware limited liability company (&quot;WP Partners GP&quot;), is the general partner of WP Partners. Warburg Pincus &amp; Co., a New York general partnership (&quot;WP&quot;), is the managing member of WP Partners GP. Warburg Pincus LLC, a New York limited liability company (&quot;WP LLC&quot;), is the manager of the WPP Funds.</footnote>
    </footnotes>

    <remarks>Due to the limitations of the SEC EDGAR filing system, the WPP Funds, WPX GP, WP X, WP X LP, WP X GP, WPP GP, WP Partners, WP Partners GP, and WP are filing a separate Form 4 from WP LLC.</remarks>

    <ownerSignature>
        <signatureName>WARBURG PINCUS LLC By: /s/ Harsha Marti Name: Harsha Marti Title: General Counsel and Managing Director</signatureName>
        <signatureDate>2021-04-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
