<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001019056-26-000002</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001426156</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock, $0.001 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001162194</issuerCik>
        <issuerName>STANDARD BIOTOOLS INC.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>34385P108</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>50 MILK STREET</com:street1>
          <com:street2>10th Floor</com:street2>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02109</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>MAK Capital Fund LP</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>D0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>26172626.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>26172626.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>26172626.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>6.7</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>The calculation is based upon 26,172,626 shares of Common Stock beneficially owned as of 05/15/2026 and a total of 390,368,119 shares of Common Stock, $0.001 par value per share, outstanding as of May 4, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 6, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>MAK Capital One L.L.C.</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>26172626.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>26172626.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>26172626.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>6.7</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <comments>The calculation is based upon 26,172,626 shares of Common Stock beneficially owned as of 05/15/2026 and a total of 390,368,119 shares of Common Stock, $0.001 par value per share, outstanding as of May 4, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 6, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Michael A. Kaufman</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>26172626.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>26172626.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>26172626.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>6.7</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>The calculation is based upon 26,172,626 shares of Common Stock beneficially owned as of 05/15/2026 and a total of 390,368,119 shares of Common Stock, $0.001 par value per share, outstanding as of May 4, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 6, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>STANDARD BIOTOOLS INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>50 MILK STREET, 10th Floor, BOSTON, MASSACHUSETTS, 02109.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This Schedule 13G/A is being filed by:

i.    MAK Capital Fund LP ("MAK Fund")

ii.   MAK Capital One L.L.C. ("MAK Capital"); and

iii.  Michael A. Kaufman ("Mr. Kaufman," and collectively with MAK Fund and MAK Capital, the "Reporting Persons")</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The principal business address of (i) MAK Fund is c/o Wakefield Quin, Victoria Place, 31 Victoria Street, Bermuda; and (ii) MAK Capital and Mr. Kaufman is 590 Madison Avenue, 31st Floor, New York, NY 10022.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>MAK Capital Fund LP is a Bermuda limited partnership.

MAK Capital One L.L.C. is a Delaware limited liability company.

Mr. Kaufman is a United States citizen.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>26,172,626</amountBeneficiallyOwned>
        <classPercent>6.7%

The calculation is based upon 26,172,626 shares of Common Stock beneficially owned as of 05/15/2026 and a total of 390,368,119 shares of Common Stock, $0.001 par value per share, outstanding as of May 4, 2026, as reported by the Issuer on its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 6, 2026.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>26,172,626</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>26,172,626</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>MAK Capital Fund LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Michael A. Kaufman</signature>
        <title>Managing Member</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>MAK Capital One L.L.C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Michael A. Kaufman</signature>
        <title>Managing Member</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Michael A. Kaufman</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Michael A. Kaufman</signature>
        <title>Michael A. Kaufman</title>
        <date>05/15/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
