X0202 4 2007-08-22 0 0001161924 MiddleBrook Pharmaceuticals, Inc. MBRK 0001263483 RUDNIC EDWARD M C/O MIDDLEBROOK PHARMACEUTICALS, INC. 20425 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 1 1 0 0 President and CEO Common Stock 2007-08-22 4 S 0 700 2.29 D 387058 D Common Stock 2007-08-22 4 S 0 2858 2.31 D 384200 D Common Stock 2007-08-22 4 S 0 4021 2.32 D 380179 D Common Stock 2007-08-22 4 S 0 200 2.33 D 379979 D Common Stock 2007-08-22 4 S 0 800 2.34 D 379179 D Common Stock 2007-08-22 4 S 0 1200 2.35 D 377979 D Common Stock 2007-08-22 4 S 0 21 2.39 D 377958 D Common Stock 2007-08-22 4 S 0 5600 2.40 D 372358 D Common Stock 2007-08-22 4 S 0 100 2.42 D 372258 D Common Stock 2007-08-22 4 S 0 400 2.425 D 371858 D Common Stock 2007-08-22 4 S 0 100 2.49 D 371758 D Common Stock 2007-08-23 4 S 0 1000 2.30 D 370758 D Common Stock 2007-08-23 4 S 0 4300 2.31 D 366458 D Common Stock 2007-08-23 4 S 0 1329 2.32 D 365129 D Common Stock 2007-08-23 4 S 0 1200 2.33 D 363929 D Common Stock 2007-08-23 4 S 0 600 2.34 D 363329 D Common Stock 2007-08-23 4 S 0 100 2.35 D 363229 D Common Stock 2007-08-23 4 S 0 300 2.36 D 362929 D Common Stock 2007-08-23 4 S 0 500 2.37 D 362429 D Common Stock 2007-08-23 4 S 0 471 2.40 D 361958 D Common Stock 2007-08-23 4 S 0 200 2.41 D 361758 D Common Stock 2007-08-23 4 S 0 1000 2.45 D 360758 D Common Stock 136606 I Held by Edward M. Rudnic 2003 Grantor Retained Annuity Trust Common Stock 136606 I Held by Elizabeth G. Rudnic Grantor Retained Annuity Trust Common Stock 87427 I Held by the Elizabeth Ashley Rudnic Special Trust Common Stock 87427 I Held by the Megan Valentia Rudnic Special Trust The Elizabeth G. Rudnic 2003 Grantor Retained Annuity Trust is held for the benefit of Elizabeth G. Rudnic, the wife of the Reporting Person. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The Elizabeth Ashley Rudnic Special Trust is held for the benefit of Elizabeth A. Rudnic, the daughter of the Reporting Person. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The Megan Valentia Rudnic Special Trust is held for the benefit of Megan V. Rudnic, the daughter of the Reporting Person. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 14, 2007. This Form 4 is the first of two forms to report the sales transactions. /s/ Robert C. Low, attorney-in-fact 2007-08-24