X0202 3 2005-11-01 0 0001161924 ADVANCIS PHARMACEUTICAL CORP AVNC 0001342816 Low Robert C 20425 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 0 1 0 0 Vice President & Acting CFO Common Stock 9300 D Stock Option (Right to Buy) 1.36 2015-10-25 Common Stock 20000 D Stock Option (Right to Buy) 0.93 2015-09-06 Common Stock 20000 D Stock Option (Right to Buy) 4.80 2015-05-24 Common Stock 30000 D Stock Option (Right to Buy) 8.40 2014-09-14 Common Stock 30000 D Stock Option (Right to Buy) 1.41 2013-09-01 Common Stock 27321 D 2.0833% of the Options become exercisable each month, commencing one month after November 15, 2005 (the "Initial Vesting Date") and on such day of every month thereafter, through the fourth anniversary of the Initial Vesting Date. 100% of the Options become exercisable on August 15, 2006 (the "Initial Vesting Date"). 2.0833% of the Options become exercisable each month, commencing one month after August 15, 2005 (the "Initial Vesting Date") and on such day of every month thereafter, through the fourth anniversary of the Initial Vesting Date. 2.083% of the Options become exercisable each month, commencing on August 15, 2004 (the "Initial Vesting Date") and on such day of every month thereafter, through the fourth anniversary of the Initial Vesting Date. 25% of the Options will vest on each of the first four anniversaries of August 28, 2003. Additional vesting rules are set forth in the Stock Option Agreement. Robert C. Low 2005-11-08