X0202 4 2004-10-22 0 0001161924 ADVANCIS PHARMACEUTICAL CORP AVNC 0001263483 RUDNIC EDWARD M C/O ADVANCIS PHARMACEUTICAL CORP. 20425 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 1 1 0 0 Chairman, President and CEO Common Stock 2004-10-22 4 S 0 600 2.55 D 338859 D Common Stock 2004-10-22 4 S 0 100 2.56 D 338759 D Common Stock 2004-10-22 4 S 0 1100 2.5664 D 337659 D Common Stock 2004-10-22 4 S 0 2000 2.58 D 335659 D Common Stock 2004-10-22 4 S 0 2100 2.5805 D 333559 D Common Stock 2004-10-22 4 S 0 3271 2.5847 D 330288 D Common Stock 2004-10-22 4 S 0 938 2.585 D 329350 D Common Stock 2004-10-22 4 S 0 1200 2.5925 D 328150 D Common Stock 2004-10-22 4 S 0 500 2.598 D 327650 D Common Stock 2004-10-22 4 S 0 800 2.60 D 326850 D Common Stock 2004-10-22 4 S 0 391 2.61 D 326459 D Common Stock 136606 I Held by Edward M. Rudnic 2003 Grantor Retained Annuity Trust Common Stock 136606 I Held by Elizabeth G. Rudnic 2003 Grantor Retained Annuity Trust Common Stock 87427 I Held by the Elizabeth Ashley Rudnic Special Trust Common Stock 87427 I Held by the Megan Valentia Rudnic Special Trust Sale made in response to a margin call by the Reporting Person's broker. The Elizabeth G. Rudnic 2003 Grantor Retained Annuity Trust is held for the benefit of Elizabeth G. Rudnic, the wife of the Reporting Person. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The Elizabeth Ashley Rudnic Special Trust is held for the benefit of Elizabeth A. Rudnic, the daughter of the Reporting Person. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The Megan Valentia Rudnic Special Trust is held for the benefit of Megan V. Rudnic, the daughter of the Reporting Person. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. /s/ Steven A. Shallcross, attorney-in-fact 2004-10-25