-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 SefpqY1kq6uRt7rfQDd2OxTxS+aU69haihKC+VeJEo0yoQ6TIA8E0GACSWp+Eel6
 D5OfBcOnWf/J8R4PZcE0dA==

<SEC-DOCUMENT>0001209191-08-051566.txt : 20080912
<SEC-HEADER>0001209191-08-051566.hdr.sgml : 20080912
<ACCEPTANCE-DATETIME>20080912083514
ACCESSION NUMBER:		0001209191-08-051566
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080910
FILED AS OF DATE:		20080912
DATE AS OF CHANGE:		20080912

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MiddleBrook Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001161924
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				522208264
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		20425 SENECA MEADOWS PARKWAY
		CITY:			GERMANTOWN
		STATE:			MD
		ZIP:			20878
		BUSINESS PHONE:		(301) 944-6600

	MAIL ADDRESS:	
		STREET 1:		20425 SENECA MEADOWS PARKWAY,
		CITY:			GERMANTOWN,
		STATE:			MD
		ZIP:			20876

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCIS PHARMACEUTICAL CORP
		DATE OF NAME CHANGE:	20011106

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BURNSIDE BETH A
		CENTRAL INDEX KEY:			0001263493

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-50414
		FILM NUMBER:		081068245

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		301 944 6600

	MAIL ADDRESS:	
		STREET 1:		20425 SENECA MEADOWS PARKWAY
		CITY:			GERMANTOWN
		STATE:			MD
		ZIP:			20876
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-09-10</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001161924</issuerCik>
        <issuerName>MiddleBrook Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>MBRK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001263493</rptOwnerCik>
            <rptOwnerName>BURNSIDE BETH A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>20425 SENECA MEADOWS PARKWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GERMANTOWN</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20876</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP, Reg Affairs, Comp &amp; Strat</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.77</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-09-10</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>216000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-09-09</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>216000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>216000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">2.083% of the Options vest and become exercisable each month, commencing one month after September 10, 2008 (the &quot;Initial Vesting Date&quot;) and on such day of every month thereafter, through the fourth anniversary of the Initial Vesting Date.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Brad Cole, Attorney-in-fact</signatureName>
        <signatureDate>2008-09-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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