<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2007-12-12</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001337013</issuerCik>
        <issuerName>InfuSystem Holdings, Inc</issuerName>
        <issuerTradingSymbol>HAPN.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001161175</rptOwnerCik>
            <rptOwnerName>KLEINHEINZ CAPITAL PARTNERS INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>201 MAIN STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2001</rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001421810</rptOwnerCik>
            <rptOwnerName>Kleinheinz Capital Partners LDC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>201 MAIN STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2001</rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001081865</rptOwnerCik>
            <rptOwnerName>KLEINHEINZ JOHN B</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>201 MAIN STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2001</rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1572480</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Warrant to Purchase Common Shares</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2007-10-26</value>
            </exerciseDate>
            <expirationDate>
                <value>2011-04-11</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>500000</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The filing of this Form 3 shall not be construed as an admission that Kleinheinz Capital Partners, Inc., Kleinheinz Capital Partners LDC or John Kleinheinz is or was for the purpose of Section 16(a) of the Securties Exchange Act of 1934, as amended, or otherwise a beneficial owner of any of the shares of common stock (&quot;Common Stock&quot;) or Warrants to purchase Common Stock (&quot;Warrants&quot;) of Infusystem Holdings, Inc. owned by Global Undervalued Securities Fund, LP, Global Undervalued Securities Fund (QP), LP, Global Undervalued Securities Fund, Ltd. or Global Undervalued Securities Master Fund, LP. Pursuant to Rule 16a-1, each of Kleinheinz Capital Partners, Inc., Kleinheinz Capital Partners LDC and John Kleinheinz disclaims such beneficial ownership.</footnote>
        <footnote id="F2">Kleinheinz Capital Partners LDC holds indirectly shares of Common Stock and Warrants on behalf of Global Undervalued Securities Fund, LP, and Global Undervalued Securities Fund (QP), LP for which Kleinheinz Capital Partners LDC serves as general partner. Kleinheinz Capital Partners, Inc. holds indirectly shares of Common Stock and Warrants on behalf of Global Undervalued Securities Fund, LP, Global Undervalued Securities Fund (QP), LP, Global Undervalued Securitites Fund, Ltd. and Global Undervalued Securities Master Fund, LP, for which Kleinheinz Capital Partners, Inc. serves as investment manager. John Kleinheinz report the shares of Common Stock and Warrants held indirectly by Kleinheinz Capital Partners LDC and Kleinheinz Capital Partners, Inc. because, as managing director and director, respectively, at the time of purchase, he controlled the voting and disposition of the securitites.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John Kleinheinz, Director of Kleinheinz Capital Partners, Inc.</signatureName>
        <signatureDate>2007-12-19</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John Kleinheinz, Managing Director of Kleinheinz Capital Partners, LDC</signatureName>
        <signatureDate>2007-12-19</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John Kleinheinz</signatureName>
        <signatureDate>2007-12-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
