<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0305</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2012-04-27</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001337013</issuerCik>
        <issuerName>InfuSystem Holdings, Inc</issuerName>
        <issuerTradingSymbol>INFU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001165595</rptOwnerCik>
            <rptOwnerName>GLOBAL UNDERVALUED SECURITIES MASTER FUND LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O BNY MELLON ALTERNATIVE INVEST. SVCS.</rptOwnerStreet1>
            <rptOwnerStreet2>48 PAR-LA-VILLE ROAD, SUITE 464</rptOwnerStreet2>
            <rptOwnerCity>HAMILTON</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode>HM 11</rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001090351</rptOwnerCik>
            <rptOwnerName>GLOBAL UNDERVALUED SECURITIES FUND LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O BNY MELLON ALTERNATIVE INVEST. SVCS.</rptOwnerStreet1>
            <rptOwnerStreet2>48 PAR-LA-VILLE ROAD, SUITE 464</rptOwnerStreet2>
            <rptOwnerCity>HAMILTON</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode>HM 11</rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001302660</rptOwnerCik>
            <rptOwnerName>Global Undervalued Securities Fund QP L P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O BNY MELLON ALTERNATIVE INVEST. SVCS.</rptOwnerStreet1>
            <rptOwnerStreet2>48 PAR-LA-VILLE ROAD, SUITE 464</rptOwnerStreet2>
            <rptOwnerCity>HAMILTON</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode>HM 11</rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001306112</rptOwnerCik>
            <rptOwnerName>Global Undervalued Securities Fund Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O BNY MELLON ALTERNATIVE INVEST. SVCS.</rptOwnerStreet1>
            <rptOwnerStreet2>48 PAR-LA-VILLE ROAD, SUITE 464</rptOwnerStreet2>
            <rptOwnerCity>HAMILTON</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode>HM 11</rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001161175</rptOwnerCik>
            <rptOwnerName>KLEINHEINZ CAPITAL PARTNERS, INC.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>301 COMMERCE STREET, SUITE 1900</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001421810</rptOwnerCik>
            <rptOwnerName>Kleinheinz Capital Partners LDC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKERS SPV LIMITED</rptOwnerStreet1>
            <rptOwnerStreet2>WALKER HOUSE, 87 MARY STREET</rptOwnerStreet2>
            <rptOwnerCity>GEORGE TOWN, GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9002</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001081865</rptOwnerCik>
            <rptOwnerName>KLEINHEINZ JOHN B</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>301 COMMERCE STREET, SUITE 1900</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>None - See Footnote (1)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1861480</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The Reporting Persons are no longer members of a group beneficially owning more than 10% of the Issuer's common stock.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz, President of Kleinheinz Capital Partners, Inc., investment manager of Global Undervalued Securities Fund, L.P., general partner of Global Undervalued Securities Master Fund, L.P.</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz, President of Kleinheinz Capital Partners, Inc., investment manager of Global Undervalued Securities Fund, L.P.</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz, President of Kleinheinz Capital Partners, Inc., investment manager of Global Undervalued Securities Fund (QP), L.P.</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz, Director of Global Undervalued Securities Fund, Ltd.</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz, President of Kleinheinz Capital Partners, Inc.</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz, Managing Director of Kleinheinz Capital Partners LDC</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John B. Kleinheinz</signatureName>
        <signatureDate>2012-05-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
