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Note 5 - Property and Equipment, Net (Tables)
 3 Months Ended
Mar. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
March 31,
201
9
    
December 31,
201
8
  
Laboratory and production equipment
   $
124,774
     $
121,716
  
Office, software and computer equipment
    
30,578
      
30,190
  
Furniture and fixtures
    
1,572
      
1,558
  
Leasehold improvements
    
7,600
      
7,609
  
     
164,524
      
161,073
  
Less accumulated depreciation
    
(95,820
 )    
(90,333
 )
    $
68,704
     $
70,740