Note 1 - Organization and Summary of Significant Accounting Policies - Useful Lives by Asset Category (Details)	12 Months Ended
	Dec. 31, 2018
Office Equipment [Member]
Estimated useful life (Year)	3 years
Software and Software Development Costs [Member]
Estimated useful life (Year)	3 years
Equipment [Member] | Minimum [Member]
Estimated useful life (Year)	2 years
Equipment [Member] | Maximum [Member]
Estimated useful life (Year)	5 years
Computer Equipment [Member]
Estimated useful life (Year)	5 years
Lab Equipment [Member]
Estimated useful life (Year)	5 years
Furniture and Fixtures [Member]
Estimated useful life (Year)	7 years