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Note 7 - Property and Equipment, Net (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
  
   
201
8
    
2017
  
Laboratory and production equipment
   $
121,716
     $
94,609
  
Office, software and computer equipment
    
30,190
      
28,594
  
Furniture and fixtures
    
1,558
      
1,698
  
Leasehold improvements
    
7,609
      
7,250
  
     
161,073
      
132,151
  
Less accumulated depreciation
    
(90,333
 )    
(71,807
 )
    $
70,740
     $
60,344