Note 7 - Property and Equipment, Net

12 Months Ended

Dec. 31, 2018

Notes to Financial Statements

Property, Plant and Equipment Disclosure [Text Block]

7

. Property and Equipment, net

Property and equipment consist of the following:

	December 31,
	201 8			2017
Laboratory and production equipment	$	121,716		$	94,609
Office, software and computer equipment		30,190			28,594
Furniture and fixtures		1,558			1,698
Leasehold improvements		7,609			7,250
		161,073			132,151
Less accumulated depreciation		(90,333	)		(71,807	)
	$	70,740		$	60,344

Depreciation and amortization expense for the years ended

December 

31,

2018,

2017

and

2016

was

$20,227,

$20,631

and

$15,943,

respectively.

As of

December 

31,

2018

and

2017,

computer software costs included in property and equipment were

$6,879

and

$7,181,

respectively. Amortization expense of capitalized computer software costs was

$591,

$1,038,

and

$1,152

for the years ended

December 

31,

2018,

2017

and

2016,

respectively.

Property and equipment

not

paid as of

December 31, 2018

and

2017

was

$2,580

and

$3,339,

respectively.