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Note 6 - Property and Equipment, Net (Tables)
12 Months Ended
Dec. 31, 2014
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment [Table Text Block]
   

December 31,

 
   

2014

   

2013

 
                 

Laboratory and production equipment

  $ 48,522     $ 34,443  

Office, software and computer equipment

    15,855       8,649  

Furniture and fixtures

    1,762       834  

Leasehold improvements

    5,212       3,952  
      71,351       47,878  

Less accumulated depreciation

    (35,853 )     (25,418 )
    $ 35,498     $ 22,460