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Acquisitions - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Apr. 27, 2017
Jan. 06, 2017
Jun. 30, 2018
Mar. 31, 2018
Sep. 30, 2018
Business Acquisition [Line Items]          
Purchase price based on the fair value of outstanding equity $ 35,846        
Impairment charges and corresponding decrease to carrying value         $ 21,692
Mast [Member]          
Business Acquisition [Line Items]          
Business combination completion date Apr. 27, 2017        
Merger agreement, effective date   Jan. 06, 2017      
Purchase price based on the fair value of outstanding equity $ 35,800        
Tax benefit related to reduction in deferred tax liability       $ 4,600  
Mast [Member] | IPR&D [Member]          
Business Acquisition [Line Items]          
Impairment charges and corresponding decrease to carrying value       21,700 $ 21,700
Tax benefit related to reduction in deferred tax liability       $ 4,600  
Cardeas [Member]          
Business Acquisition [Line Items]          
Common stock upfront payment, shares     107,579    
Common stock upfront payment, value     $ 1,000