Consolidated Statements of Cash Flows - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities:
Net loss		$ (38,150)	$ (43,014)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		31	136
Amortization of right-of-use assets		136	231
Non-cash interest income			(103)
Foreign currency loss		19	99
Amortization of debt issuance costs		334	552
Amortization on premium to short-term investments, net		75	1,604
Stock-based compensation		2,041	3,260
Changes in operating assets and liabilities:
Prepaid expenses and other current assets		1,336	(1,039)
Non-current assets		(57)
Accounts payable and accrued expenses and other current liabilities		(319)	(1,763)
Long-term liabilities			(44)
Net cash used in operating activities		(34,554)	(40,081)
Cash flows from investing activities:
Purchase of property and equipment		(9)	(57)
Purchase of available-for-sale securities, net		(89,415)	(161,069)
Maturity of available-for-sale securities		130,793	83,470
Sale of available-for-sale securities, net		11,276	8,200
Net cash provided by (used in) investing activities		52,645	(69,456)
Cash flows from financing activities:
Repurchase of outstanding pre-funded warrants			(3,909)
Repayment of long-term debt	[1]	(26,350)
Proceeds from long-term debt, net	[1]	26,438
Issuance of common stock and pre-funded warrants in public offering, net of offering costs			122,231
Issuance of common stock upon exercise of warrants, net			2,546
Proceeds from exercise of stock options		2	16
Repurchase of shares for minimum tax withholdings		(3)	(78)
Net cash provided by financing activities		87	120,806
Effect of exchange rate changes on cash and cash equivalents		(90)	(137)
Increase in cash and cash equivalents		18,088	11,132
Cash and cash equivalents beginning of period		34,012	22,880
Cash and cash equivalents end of period		52,100	34,012
Supplemental disclosure of cash flow information:
Cash paid for interest		$ 1,614	$ 1,969

[1] As discussed in Note 7. Debt Facility, the Amended Loan Agreement (as defined herein) was accounted for as a modification. The Company used the proceeds from the Amended Loan Agreement to repay the outstanding amounts under the Loan Agreement from Silicon Valley Bank.