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Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $)
9 Months Ended186 Months Ended
Sep. 30, 2011
Sep. 30, 2010
Sep. 30, 2011
Cash flows from operating activities:   
Net loss$ (10,887,955)$ (6,166,415)$ (169,245,683)
Adjustments to reconcile net loss to net cash used in operating activities:   
Depreciation and amortization28,73516,52610,476,355
(Gain) loss on disposals of fixed assets(2,973)2,01956,812
Loss on fair value of warrants  12,239,688
Gain on change in fair value of contingent consideration(318,785) (318,785)
Expenses related to share-based compensation533,704604,7729,757,646
Expense related to stock options issued to non-employees  204,664
Expenses paid by issuance of common stock  1,341,372
Expenses paid by issuance of warrants  573,357
Expenses paid by issuance of preferred stock  142,501
Expenses related to stock warrants issued  612,000
Accretion of discount on investments in securities  (1,604,494)
Amortization of debt discount  450,000
Forgiveness of employee receivable  30,036
Impairment loss - write-off of goodwill  5,702,130
Equity in loss of investee  178,936
In-process research and development  10,422,130
Write-off of license agreement  152,866
Write-off of assets available-for-sale  108,000
Cumulative effect of change in accounting principle  25,821
Changes in assets and liabilities, net of effect of acquisitions:   
Increase in prepaid expenses and other assets(154,146)(186,929)(865,256)
Increase (decrease) in accounts payable and accrued liabilities374,755(1,277,316)2,352,939
Net cash used in operating activities(10,426,665)(7,007,343)(117,206,965)
Cash flows from investing activities:   
Purchases of short-term investments  (111,183,884)
Proceeds from sales and maturities of short-term investments  112,788,378
Purchases of property and equipment(208,982)(6,780)(1,267,849)
Proceeds from sale of property and equipment12,6351,70066,920
Purchase of certificate of deposits(5,523,201) (6,539,531)
Maturity of certificate of deposits  1,016,330
Payment on obligation under license agreement  (106,250)
Cash acquired from acquisitions, net of cash paid  32,395
Issuance of note receivable - related party  (35,000)
Payments on note receivable  405,993
Advance to investee  (90,475)
Cash transferred in rescission of acquisition  (19,475)
Cash received in rescission of acquisition  230,000
Net cash provided by (used in) investing activities(5,719,548)(5,080)(4,702,448)
Cash flows from financing activities:   
Proceeds from sale of preferred stock 30,453,22744,474,720
Proceeds of restricted cash for preferred stock dividends 633,008633,008
Proceeds from sale of common stock22,507,529 106,658,871
Proceeds from exercise of stock options  712,367
Proceeds from sale or exercise of warrants 317,44414,714,258
Payment to escrow for preferred stock dividends obligation (633,008)(633,008)
Repurchase of warrants  (55,279)
Payments for financing and offering costs(1,548,123)(3,093,733)(12,542,171)
Payments on notes payable and long-term debt  (605,909)
Proceeds from issuance of notes payable and detachable warrants  1,344,718
Cash paid in lieu of fractional shares for reverse stock split (146)(146)
Net cash provided by financing activities20,959,40627,676,792154,701,429
Effect of exchange rate changes on cash(23,128) (23,128)
Net increase in cash and cash equivalents4,790,06520,664,36932,768,888
Cash and cash equivalents at beginning of period27,978,823[1]8,667,404 
Cash and cash equivalents at end of period$ 32,768,888$ 29,331,773$ 32,768,888
[1] The balance sheet at December 31, 2010 has been derived from audited financial statements at that date. It does not include, however, all of the information and notes required by accounting principles generally accepted in the United States of America for complete financial statements.