144 0001910662 XXXXXXXX LIVE 0001159036 HALOZYME THERAPEUTICS INC 001-32335 12390 El Camino Real San Diego CA 92130 858-794-8889 NICOLE LABROSSE Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

22227 1690807.89 116966000 09/10/2025 NASDAQ Common 09/10/2025 Exercise of Stock Options Issuer N 12406 09/10/2025 Cash Common 02/10/2023 Restricted Stock Units Issuer N 9821 02/10/2023 N/A Y The securities to be sold were acquired upon the vesting of restricted stock units during the period of 02/10/2023 through 02/16/2024. 09/10/2025 06/11/2025 /s/ Nicole Labrosse