144 0001518611 XXXXXXXX LIVE 0001157601 Madrigal Pharmaceuticals, Inc. 001-33277 1001 Conshohocken State Road Suite 2-350 West Conshohocken PA 19428 267-824-2827 William John Sibold Officer and Director Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza, 8th Floor New York NY 10004 6362 3398325.92 23104126 09/09/2026 Nasdaq Stock Market Common Stock 09/08/2026 Restricted Stock Unit Grant Issuer N 6362 09/08/2026 Vesting of Restricted Stock Units N William John Sibold c/o Madrigal Pharmaceuticals, Inc. 1001 Conshohocken State Road Suite 2-350 West Conshohocken PA 19428 common stock 07/20/2026 2500 1368250 The sale reported herein represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover certain tax withholding obligations in connection with the vesting of Restricted Stock Units previously granted to the Reporting Person. This sale was automatic and not at the discretion of the Reporting Person. 09/09/2026 /s/ William Sibold