144 0001591475 XXXXXXXX LIVE 0001157601 Madrigal Pharmaceuticals, Inc. Four Towers Bridge 200 Barr Harbor Drive, Suite 200 West Conshohocken PA 19428 267-824-2827 David Soergel Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza, 8th Floor New York NY 10004 844 441994.36 23055659 05/18/2026 Nasdaq Stock Market Common Stock 05/15/2026 Restricted Stock Unit Grant Issuer N 844 05/18/2026 Vesting of Restricted Stock Units Y The sale of shares of common stock reported on this Form 144 represents the sale of shares pursuant to a sell-to-cover transaction in order to satisfy tax withholding obligations in connection with the vesting of Restricted Stock Units previously granted to the Reporting Person. 05/18/2026 /s/ David Soergel