144 0002001571 XXXXXXXX LIVE 0001157601 Madrigal Pharmaceuticals, Inc. 001-33277 Four Tower Bridge 200 Barr Harbor Drive West Conshohocken PA 19428 2678242827 Carole Huntsman Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

894 484655.28 22711420 11/21/2025 Nasdaq Stock Market Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

1064 576815.68 22711420 11/21/2025 Nasdaq Stock Market Common Stock 11/20/2025 Restricted Stock Unit Grant Issuer N 894 11/20/2025 Vesting of Restricted Stock Units Common Stock 11/20/2025 Restricted Stock Unit Grant Issuer N 1064 11/20/2025 Vesting of Restricted Stock Units Y The sale of shares of common stock reported on this Form 144 represents (i) the sale of 894 shares pursuant to a sell-to-cover transaction in order to satisfy tax withholding obligations in connection with the vesting of Restricted Stock Units previously granted to the Reporting Person and (ii) the automatic sale of 1,064 shares pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on 11/05/2024. Aggregate market value is based on a closing stock price of $542.12 for the Issuer's Common Stock on 11/20/25. 11/21/2025 11/05/2024 /s/ Carole Huntsman