Stock-based Compensation - Narrative (Details) - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Unrecognized stock-based compensation expense
Stock options, restricted stock and performance stock units convertible, shares issuable (in shares)	2,263,222
Inducement Plan 2023
Unrecognized stock-based compensation expense
Shares available for future issuance (in shares)	25,176
Common stock reserved for future issuance (in shares)	500,000
Maximum | Stock Plan 2015
Unrecognized stock-based compensation expense
Expiration period	10 years
Maximum | Inducement Plan 2023
Unrecognized stock-based compensation expense
Expiration period	10 years
Common stock options
Unrecognized stock-based compensation expense
Proceeds resulting from exercise of stock options	$ 76.9	$ 34.0	$ 9.0
Total intrinsic value of options exercised	$ 167.8	$ 70.4	$ 47.3
Weighted-average grant date fair value of options (in dollars per share)	$ 155.42	$ 149.15	$ 54.68
Unrecognized stock compensation expense	$ 127.3
Weighted average remaining period (in years)	2 years 7 months 6 days
Common stock options | Stock Plan 2015
Unrecognized stock-based compensation expense
Shares available for future issuance (in shares)	1,205,990
Restricted stock units
Unrecognized stock-based compensation expense
Equity instruments other than options, outstanding (in shares)	499,559	376,117
Equity instruments other than options, weighted average grant date fair value (in dollars per share)	$ 237.07	$ 241.45
Restricted stock units | Stock Plan 2015
Unrecognized stock-based compensation expense
Equity instruments other than options, outstanding (in shares)	499,559