Accrued Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Contract research organization costs	$ 57,984	$ 53,119
Other clinical study related costs	6,638	6,582
Manufacturing and drug supply	2,996	11,262
Compensation and benefits	11,208	14,864
Professional fees	4,741	4,867
Other	2,000	767
Total accrued liabilities	$ 85,567	$ 91,461