Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock	Common stock	Additional paid-in Capital	Accumulated other comprehensive income (loss)	Accumulated deficit
Balance at Dec. 31, 2019	$ 416,565		$ 2	$ 639,567	$ 216	$ (223,220)
Balance (in shares) at Dec. 31, 2019		1,969,797	15,429,154
Increase (Decrease) in Stockholders' Equity
Issuance of common and preferred shares in equity offerings, excluding to related parties, net of transaction costs	4,421			4,421
Issuance of common and preferred shares in equity offerings, excluding to related parties, net of transaction costs (in shares)			39,607
Sale of common shares to related parties and exercise of common stock options, net of transaction cost	667			667
Sale of common shares to related parties and exercise of common stock options, net of transaction cost ( in shares)			39,385
Compensation expense related to stock options for services	20,730			20,730
Unrealized loss on marketable securities	(169)				(169)
Net loss	(202,244)					(202,244)
Balance at Dec. 31, 2020	239,970		$ 2	665,385	47	(425,464)
Balance (in shares) at Dec. 31, 2020		1,969,797	15,508,146
Increase (Decrease) in Stockholders' Equity
Issuance of common and preferred shares in equity offerings, excluding to related parties, net of transaction costs	170,207			170,207
Issuance of common and preferred shares in equity offerings, excluding to related parties, net of transaction costs (in shares)			1,584,169
Sale of common shares to related parties and exercise of common stock options, net of transaction cost	1,030			1,030
Sale of common shares to related parties and exercise of common stock options, net of transaction cost ( in shares)			11,080
Compensation expense related to stock options for services	26,873			26,873
Unrealized loss on marketable securities	(127)				(127)
Net loss	(241,846)					(241,846)
Balance at Dec. 31, 2021	$ 196,107		$ 2	863,495	(80)	(667,310)
Balance (in shares) at Dec. 31, 2021	17,103,395	1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Issuance of common and preferred shares in equity offerings, excluding to related parties, net of transaction costs	$ 255,382			255,382
Issuance of common and preferred shares in equity offerings, excluding to related parties, net of transaction costs (in shares)		400,000	783,344
Sale of common shares to related parties and exercise of common stock options, net of transaction cost	8,955			8,955
Sale of common shares to related parties and exercise of common stock options, net of transaction cost ( in shares)			215,784
Compensation expense related to stock options for services	31,625			31,625
Unrealized loss on marketable securities	48				48
Hercules warrant	622			622
Net loss	(295,350)					(295,350)
Balance at Dec. 31, 2022	$ 197,389		$ 2	$ 1,160,079	$ (32)	$ (962,660)
Balance (in shares) at Dec. 31, 2022	18,102,523	2,369,797	18,102,523