Quarterly Financial Data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2022

Quarterly Financial Information Disclosure [Abstract]

Schedule of quarterly results of operations

The following tables present a summary of quarterly results of operations for 2022 and 2021 (in thousands, except shares and per share data):

	Three months ended
	March 31, 2022			June 30, 2022			September 30, 2022			December 31, 2022
Revenues:
Total revenues	$	—		$	—		$	—		$	—
Operating expenses:
Research and development		47,929			58,499			68,271			70,742
General and administrative		9,658			11,774			12,141			14,557
Total operating expenses		57,587			70,273			80,412			85,299
Loss from operations		(57,587	)		(70,273	)		(80,412	)		(85,299	)
Interest income		69			323			717			1,076
Interest expense		—			(780	)		(1,502	)		(1,682	)
Other income		—			—			—			—
Net loss	$	(57,518	)	$	(70,730	)	$	(81,197	)	$	(85,905	)
Net loss per common share:
Basic and diluted net loss per common share	$	(3.36	)	$	(4.14	)	$	(4.75	)	$	(4.98	)
Basic and diluted weighted average number of common shares outstanding		17,103,395			17,103,395			17,103,395			17,237,517

	Three months ended
	March 31, 2021			June 30, 2021			September 30, 2021			December 31, 2021
Revenues:
Total revenues	$	—		$	—		$	—		$	—
Operating expenses:
Research and development		45,770			51,632			54,873			52,889
General and administrative		7,209			10,110			8,287			11,712
Total operating expenses		52,979			61,742			63,160			64,601
Loss from operations		(52,979	)		(61,742	)		(63,160	)		(64,601	)
Interest income		160			91			60			52
Interest expense		—			—			—			—
Other income		273			—			—			—
Net loss	$	(52,546	)	$	(61,651	)	$	(63,100	)	$	(64,549	)
Net loss per common share:
Basic and diluted net loss per common share	$	(3.32	)	$	(3.72	)	$	(3.79	)	$	(3.78	)
Basic and diluted weighted average number of common shares outstanding		15,840,401			16,571,322			16,639,776			17,074,543