Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock	Common stock	Additional paid-in Capital	Accumulated other comprehensive income (loss)	Accumulated deficit
Balance at Dec. 31, 2020	$ 239,970		$ 2	$ 665,385	$ 47	$ (425,464)
Balance (in shares) at Dec. 31, 2020		1,969,797	15,508,146
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	66,616		$ 0	66,616
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			550,803
Sale of common shares to related parties and exercise of common stock options, net of transaction costs	478			478
Sale of common shares to related parties and exercise of common stock options, net of transaction costs ( in shares)			4,250
Compensation expense related to stock options for services	6,096			6,096
Unrealized gain (loss) on marketable securities	(61)				(61)
Net loss	(52,546)					(52,546)
Balance at Mar. 31, 2021	260,553		$ 2	738,575	(14)	(478,010)
Balance (in shares) at Mar. 31, 2021		1,969,797	16,063,199
Balance at Dec. 31, 2020	239,970		$ 2	665,385	47	(425,464)
Balance (in shares) at Dec. 31, 2020		1,969,797	15,508,146
Increase (Decrease) in Stockholders' Equity
Unrealized gain (loss) on marketable securities	(43)
Net loss	(177,297)
Balance at Sep. 30, 2021	234,881		$ 2	837,636	4	(602,761)
Balance (in shares) at Sep. 30, 2021		1,969,797	16,860,211
Balance at Mar. 31, 2021	260,553		$ 2	738,575	(14)	(478,010)
Balance (in shares) at Mar. 31, 2021		1,969,797	16,063,199
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	63,541		$ 0	63,541
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			536,323
Compensation expense related to stock options for services	8,179			8,179
Unrealized gain (loss) on marketable securities	29				29
Net loss	(61,651)					(61,651)
Balance at Jun. 30, 2021	270,651		$ 2	810,295	15	(539,661)
Balance (in shares) at Jun. 30, 2021		1,969,797	16,599,522
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	21,092		$ 0	21,092
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			260,164
Sale of common shares to related parties and exercise of common stock options, net of transaction costs	8			8
Sale of common shares to related parties and exercise of common stock options, net of transaction costs ( in shares)			525
Compensation expense related to stock options for services	6,241			6,241
Unrealized gain (loss) on marketable securities	(11)				(11)
Net loss	(63,100)					(63,100)
Balance at Sep. 30, 2021	234,881		$ 2	837,636	4	(602,761)
Balance (in shares) at Sep. 30, 2021		1,969,797	16,860,211
Balance at Dec. 31, 2021	$ 196,107		$ 2	863,495	(80)	(667,310)
Balance (in shares) at Dec. 31, 2021	17,103,395	1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Compensation expense related to stock options for services	$ 7,477			7,477
Unrealized gain (loss) on marketable securities	(322)				(322)
Net loss	(57,518)					(57,518)
Balance at Mar. 31, 2022	145,744		$ 2	870,972	(402)	(724,828)
Balance (in shares) at Mar. 31, 2022		1,969,797	17,103,395
Balance at Dec. 31, 2021	$ 196,107		$ 2	863,495	(80)	(667,310)
Balance (in shares) at Dec. 31, 2021	17,103,395	1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Unrealized gain (loss) on marketable securities	$ (157)
Net loss	(209,445)
Balance at Sep. 30, 2022	$ 10,670		$ 2	887,660	(237)	(876,755)
Balance (in shares) at Sep. 30, 2022	17,103,395	1,969,797	17,103,395
Balance at Mar. 31, 2022	$ 145,744		$ 2	870,972	(402)	(724,828)
Balance (in shares) at Mar. 31, 2022		1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Compensation expense related to stock options for services	7,944			7,944
Unrealized gain (loss) on marketable securities	(45)				(45)
Hercules warrant	622			622
Net loss	(70,730)					(70,730)
Balance at Jun. 30, 2022	83,535		$ 2	879,538	(447)	(795,558)
Balance (in shares) at Jun. 30, 2022		1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Compensation expense related to stock options for services	8,122			8,122
Unrealized gain (loss) on marketable securities	210				210
Net loss	(81,197)					(81,197)
Balance at Sep. 30, 2022	$ 10,670		$ 2	$ 887,660	$ (237)	$ (876,755)
Balance (in shares) at Sep. 30, 2022	17,103,395	1,969,797	17,103,395