Stock-based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Stock-based compensation expense
Stock-based compensation expense	$ 8,122	$ 6,241	$ 23,543	$ 20,517
Research and development
Stock-based compensation expense
Stock-based compensation expense	3,596	2,622	10,084	8,120
General and administrative
Stock-based compensation expense
Stock-based compensation expense	4,526	3,619	13,459	12,397
Stock options
Stock-based compensation expense
Stock-based compensation expense	$ 8,122	$ 6,241	$ 23,543	$ 20,517