Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock	Common stock	Additional paid-in Capital	Accumulated other comprehensive income (loss)	Accumulated deficit
Balance at Dec. 31, 2018	$ 476,984		$ 2	$ 616,573	$ (319)	$ (139,272)
Balance (in shares) at Dec. 31, 2018		1,969,797	15,409,023
Increase (Decrease) in Stockholders' Equity
Sale of common shares to related parties and exercise of common stock options, net of transaction cost	235			235
Sale of common shares to related parties and exercise of common stock options, net of transaction cost ( in shares)			20,131
Compensation expense related to stock options for services	22,759			22,759
Unrealized gain (loss) on marketable securities	535				535
Net loss	(83,948)					(83,948)
Balance at Dec. 31, 2019	416,565		$ 2	639,567	216	(223,220)
Balance (in shares) at Dec. 31, 2019		1,969,797	15,429,154
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	4,421		$ 0	4,421
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			39,607
Sale of common shares to related parties and exercise of common stock options, net of transaction cost	667			667
Sale of common shares to related parties and exercise of common stock options, net of transaction cost ( in shares)			39,385
Compensation expense related to stock options for services	20,730			20,730
Unrealized gain (loss) on marketable securities	(169)				(169)
Net loss	(202,244)					(202,244)
Balance at Dec. 31, 2020	$ 239,970		$ 2	665,385	47	(425,464)
Balance (in shares) at Dec. 31, 2020	15,508,146	1,969,797	15,508,146
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	$ 170,207			170,207
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			1,584,169
Sale of common shares to related parties and exercise of common stock options, net of transaction cost	1,030			1,030
Sale of common shares to related parties and exercise of common stock options, net of transaction cost ( in shares)			11,080
Compensation expense related to stock options for services	26,873			26,873
Unrealized gain (loss) on marketable securities	(127)				(127)
Net loss	(241,846)					(241,846)
Balance at Dec. 31, 2021	$ 196,107		$ 2	$ 863,495	$ (80)	$ (667,310)
Balance (in shares) at Dec. 31, 2021	17,103,395	1,969,797	17,103,395