Quarterly Financial Data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2021

Quarterly Financial Information Disclosure [Abstract]

Schedule of quarterly results of operations

The following tables present a summary of quarterly results of operations for 2021 and 2020 (in thousands, except shares and per share data):

	Three months ended
	March 31, 2021			June 30, 2021			September 30, 2021			December 31, 2021
Revenues:
Total revenues	$	—		$	—		$	—		$	—
Operating expenses:
Research and development		45,770			51,632			54,873			52,889
General and administrative		7,209			10,110			8,287			11,712
Total operating expenses		52,979			61,742			63,160			64,601
Loss from operations		(52,979	)		(61,742	)		(63,160	)		(64,601	)
Interest income		160			91			60			52
Other income		273			—			—			—
Net loss	$	(52,546)		$	(61,651)		$	(63,100)		$	(64,549)
Net loss per common share:
Basic and diluted net loss per common share	$	(3.32)		$	(3.72)		$	(3.79)		$	(3.78)
Basic and diluted weighted average number of common shares outstanding		15,840,401			16,571,322			16,639,776			17,074,543

	Three months ended
	March 31, 2020			June 30, 2020			September 30, 2020			December 31, 2020
Revenues:
Total revenues	$	—		$	—		$	—		$	—
Operating expenses:
Research and development		33,400			44,688			53,292			53,429
General and administrative		4,605			5,639			5,494			6,126
Total operating expenses		38,005			50,327			58,786			59,555
Loss from operations		(38,005	)		(50,327	)		(58,786	)		(59,555	)
Interest income		1,870			1,204			823			432
Other income		—			100			—			—
Net loss	$	(36,135)		$	(49,023)		$	(57,963)		$	(59,123)
Net loss per common share:
Basic and diluted net loss per common share	$	(2.34)		$	(3.18)		$	(3.75)		$	(3.82)
Basic and diluted weighted average number of common shares outstanding		15,429,154			15,433,348			15,448,425			15,475,291