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Quarterly Financial Data (unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Operating expenses:                      
Research and development $ 24,910 $ 19,447 $ 15,594 $ 12,373 $ 8,871 $ 6,211 $ 5,109 $ 5,198 $ 72,324 $ 25,389 $ 24,390
General and administrative 5,044 4,748 7,110 5,746 5,583 5,122 2,717 1,871 22,648 15,293 7,672
Total operating expenses 29,954 24,195 22,704 18,119 14,454 11,333 7,826 7,069 94,972 40,682 32,062
Loss from operations (29,954) (24,195) (22,704) (18,119) (14,454) (11,333) (7,826) (7,069) (94,972) (40,682) (32,062)
Interest income 2,214 2,766 3,005 3,039 2,979 2,821 1,166 705      
Other income             200     200 350
Net loss $ (27,740) $ (21,429) $ (19,699) $ (15,080) $ (11,475) $ (8,512) $ (6,460) $ (6,364) $ (83,948) $ (32,811) $ (31,154)
Basic and diluted net loss per common share (in dollars per share) $ (1.80) $ (1.39) $ (1.28) $ (0.98) $ (0.75) $ (0.56) $ (0.45) $ (0.45) $ (5.45) $ (2.22) $ (2.54)
Basic and diluted weighted average number of common shares outstanding 15,429,154 15,415,096 15,368,986 15,364,465 15,348,358 15,307,872 14,383,720 14,127,868 15,394,659 14,796,712 12,244,939