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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Cash flows from operating activities:    
Net loss $ (20,707)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic $ (23,557)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 1,710us-gaap_ShareBasedCompensation 2,586us-gaap_ShareBasedCompensation
Depreciation and amortization 169us-gaap_DepreciationDepletionAndAmortization 168us-gaap_DepreciationDepletionAndAmortization
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 289us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets 153us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Other assets (259)us-gaap_IncreaseDecreaseInOtherNoncurrentAssets 32us-gaap_IncreaseDecreaseInOtherNoncurrentAssets
Accounts payable 598us-gaap_IncreaseDecreaseInAccountsPayableTrade (780)us-gaap_IncreaseDecreaseInAccountsPayableTrade
Accrued contract research costs 194snta_IncreaseDecreaseAccruedContractAndResearchCosts 2,081snta_IncreaseDecreaseAccruedContractAndResearchCosts
Other accrued liabilities (769)us-gaap_IncreaseDecreaseInOtherAccruedLiabilities (953)us-gaap_IncreaseDecreaseInOtherAccruedLiabilities
Net cash used in operating activities (18,775)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (20,270)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities:    
Purchases of marketable securities (28,683)us-gaap_PaymentsToAcquireAvailableForSaleSecurities (3,548)us-gaap_PaymentsToAcquireAvailableForSaleSecurities
Maturities of marketable securities 37,000us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities 19,768us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities
Purchases of property and equipment   (23)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Net cash provided by investing activities 8,317us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations 16,197us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of transaction costs, and exercise of common stock options   10,118us-gaap_ProceedsFromIssuanceOfCommonStock
Payment of term loans (2,301)us-gaap_RepaymentsOfSecuredDebt (2,490)us-gaap_RepaymentsOfSecuredDebt
Payment of capital lease obligations (10)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations (11)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations
Net cash (used in) provided by financing activities (2,311)us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 7,617us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Net (decrease) increase in cash and cash equivalents (12,769)us-gaap_NetCashProvidedByUsedInContinuingOperations 3,544us-gaap_NetCashProvidedByUsedInContinuingOperations
Cash and cash equivalents at beginning of period 46,024us-gaap_CashAndCashEquivalentsAtCarryingValue 48,490us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents at end of period 33,255us-gaap_CashAndCashEquivalentsAtCarryingValue 52,034us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosure of cash flow information:    
Cash paid for interest $ 325us-gaap_InterestPaid $ 560us-gaap_InterestPaid