The cumulative amount of depreciation, depletion and amortization (related to property, plant and equipment, but not including land) that has been recognized in the income statement.

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Gross amount of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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- Definition

Amount, net of accumulated depreciation, depletion and amortization, of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Property and Equipment (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011	Dec. 31, 2011
Property and Equipment
Property and equipment, gross	$ 21,186		$ 21,186		$ 20,765
Less accumulated depreciation and amortization	(19,981)		(19,981)		(19,358)
Property and equipment, net	1,205		1,205		1,407
Depreciation and amortization	200	400	623	1,173
Laboratory equipment
Property and Equipment
Property and equipment, gross	12,531		12,531		12,468
Leasehold improvements
Property and Equipment
Property and equipment, gross	4,939		4,939		4,847
Computers and software
Property and Equipment
Property and equipment, gross	2,546		2,546		2,315
Furniture and fixtures
Property and Equipment
Property and equipment, gross	$ 1,170		$ 1,170		$ 1,135