<SEC-DOCUMENT>0001047469-18-004274-index.html : 20180606
<SEC-HEADER>0001047469-18-004274.hdr.sgml : 20180606
<ACCEPTANCE-DATETIME>20180605190113
ACCESSION NUMBER:		0001047469-18-004274
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20180606
DATE AS OF CHANGE:		20180605

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MADRIGAL PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001157601
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-225434
		FILM NUMBER:		18882627

	BUSINESS ADDRESS:	
		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428
		BUSINESS PHONE:		404-380-9263

	MAIL ADDRESS:	
		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SYNTA PHARMACEUTICALS CORP
		DATE OF NAME CHANGE:	20010815
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>a2235926z424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: a2235926z424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g467069.jpg
<DESCRIPTION>G467069.JPG
<TEXT>
Document 2 - file: g467069.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g251621.jpg
<DESCRIPTION>G251621.JPG
<TEXT>
Document 3 - file: g251621.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g411905.jpg
<DESCRIPTION>G411905.JPG
<TEXT>
Document 4 - file: g411905.jpg

</DOCUMENT>
</SEC-DOCUMENT>