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Stock-based Compensation - Stock Option and Restricted Share Activity (Details) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Stock options    
Stock-based compensation expense    
Shares available for future issuance 651,261  
Shares    
Options carried forward at merger (in shares) 148,115  
Options granted (in shares) 772,410  
Options cancelled (in shares) (136,514)  
Outstanding at the end of the period (in shares) 784,011  
Exercisable at the end of the period (in shares) 146,668  
Weighted average exercise price    
Options carried forward at merger (in dollars per share) 113.96  
Options granted (in dollars per share) $ 9.51  
Options cancelled (in dollars per share) 116.06  
Outstanding at the end of the period (in dollars per share) 10.70  
Exercisable at the end of the period (in dollars per share) $ 12.47  
Weighted average remaining contractual life (years)    
Outstanding at the end of the period 9 years 6 months 18 days  
Exercisable at the end of the period 9 years 6 months 4 days  
Aggregate intrinsic value    
Outstanding at the end of the period $ 4,162,179  
Exercisable at the end of the period 773,066  
Additional disclosures    
Total cash received from stock option exercises $ 0 $ 0
Weighted-average grant date fair value of options (in dollars per share) $ 7.50 $ 0.00
Stock options | Maximum    
Stock-based compensation expense    
Expiration period 10 years  
Restricted stock    
Shares    
Restricted stock carried forward at merger (in shares) 2,142  
Granted (in shares) 208,255  
Vested (in shares) (53,135)  
Outstanding at the end of the period (in shares) 157,262  
Weighted average grant date fair value    
Restricted stock carried forward at merger (in dollars per share) $ 99.75  
Granted (in dollars per share) 9.45  
Vested (in dollars per share) 11.27  
Outstanding at the end of the period (in dollars per share) $ 10.06