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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Cash flows from operating activities:      
Net loss $ (86,161)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic $ (90,192)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic $ (62,790)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation expense 7,431us-gaap_ShareBasedCompensation 6,030us-gaap_ShareBasedCompensation 3,322us-gaap_ShareBasedCompensation
Depreciation and amortization 673us-gaap_DepreciationDepletionAndAmortization 516us-gaap_DepreciationDepletionAndAmortization 738us-gaap_DepreciationDepletionAndAmortization
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets 102us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets 21us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (225)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Other assets 111us-gaap_IncreaseDecreaseInOtherNoncurrentAssets (951)us-gaap_IncreaseDecreaseInOtherNoncurrentAssets 173us-gaap_IncreaseDecreaseInOtherNoncurrentAssets
Accounts payable (3,450)us-gaap_IncreaseDecreaseInAccountsPayableTrade 928us-gaap_IncreaseDecreaseInAccountsPayableTrade 2,194us-gaap_IncreaseDecreaseInAccountsPayableTrade
Accrued contract research costs 1,910snta_IncreaseDecreaseAccruedContractAndResearchCosts 5,646snta_IncreaseDecreaseAccruedContractAndResearchCosts 1,920snta_IncreaseDecreaseAccruedContractAndResearchCosts
Other accrued liabilities 459us-gaap_IncreaseDecreaseInOtherAccruedLiabilities 591us-gaap_IncreaseDecreaseInOtherAccruedLiabilities 533us-gaap_IncreaseDecreaseInOtherAccruedLiabilities
Net cash used in operating activities (78,925)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (77,411)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (54,135)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities:      
Purchases of marketable securities (93,845)us-gaap_PaymentsToAcquireAvailableForSaleSecurities (114,151)us-gaap_PaymentsToAcquireAvailableForSaleSecurities (50,033)us-gaap_PaymentsToAcquireAvailableForSaleSecurities
Maturities of marketable securities 85,152us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities 90,267us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities 40,595us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities
Purchases of property and equipment (144)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (769)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (505)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Net cash used in investing activities (8,837)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (24,653)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (9,943)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities:      
Proceeds from issuances of common stock, excluding to related parties, and exercise of common stock options, net of transaction costs 89,796us-gaap_ProceedsFromIssuanceOfCommonStock 38,735us-gaap_ProceedsFromIssuanceOfCommonStock 66,248us-gaap_ProceedsFromIssuanceOfCommonStock
Proceeds from the sale of common stock to related parties 4,992snta_ProceedsFromIssuanceOfCommonStockToRelatedParties 19,437snta_ProceedsFromIssuanceOfCommonStockToRelatedParties 53,545snta_ProceedsFromIssuanceOfCommonStockToRelatedParties
Purchase and retirement of common stock from an officer     (32)us-gaap_PaymentsForRepurchaseOfCommonStock
Proceeds from term loans   13,500us-gaap_ProceedsFromIssuanceOfSecuredDebt  
Payment of term loans (9,450)us-gaap_RepaymentsOfSecuredDebt (2,617)us-gaap_RepaymentsOfSecuredDebt (4,234)us-gaap_RepaymentsOfSecuredDebt
Payment of capital lease obligations (42)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations (13)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations (12)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations
Net cash provided by financing activities 85,296us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 69,042us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 115,515us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Net increase (decrease) in cash and cash equivalents (2,466)us-gaap_NetCashProvidedByUsedInContinuingOperations (33,022)us-gaap_NetCashProvidedByUsedInContinuingOperations 51,437us-gaap_NetCashProvidedByUsedInContinuingOperations
Cash and cash equivalents at beginning of period 48,490us-gaap_CashAndCashEquivalentsAtCarryingValue 81,512us-gaap_CashAndCashEquivalentsAtCarryingValue 30,075us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents at end of period 46,024us-gaap_CashAndCashEquivalentsAtCarryingValue 48,490us-gaap_CashAndCashEquivalentsAtCarryingValue 81,512us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosure of cash flow information:      
Cash paid for interest 1,875us-gaap_InterestPaid 2,512us-gaap_InterestPaid 1,696us-gaap_InterestPaid
Assets acquired under capital lease   $ 126us-gaap_CapitalLeaseObligationsIncurred