Property and Equipment (Details) (USD $)	12 Months Ended
Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Property and Equipment
Property and equipment, gross	$ 21,270,000	$ 20,765,000
Less accumulated depreciation and amortization	(20,096,000)	(19,358,000)
Property and equipment, net	1,174,000	1,407,000
Depreciation and amortization	738,000	1,464,000	1,933,000
Laboratory equipment
Property and Equipment
Property and equipment, gross	12,531,000	12,468,000
Leasehold improvements
Property and Equipment
Property and equipment, gross	4,939,000	4,847,000
Computers and software
Property and Equipment
Property and equipment, gross	2,630,000	2,315,000
Furniture and fixtures
Property and Equipment
Property and equipment, gross	1,170,000	1,135,000
Equipment under capital lease
Property and Equipment
Less accumulated depreciation and amortization	(57,000)	(43,000)
Property and equipment, net	$ 1,000	$ 16,000

The cumulative amount of depreciation, depletion and amortization (related to property, plant and equipment, but not including land) that has been recognized in the income statement.

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Gross amount of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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- Definition

Amount, net of accumulated depreciation, depletion and amortization, of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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