<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001212853</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001156375</issuerCik>
      <issuerName>CME GROUP INC.</issuerName>
      <secFileNumber>001-31553</secFileNumber>
      <issuerAddress>
        <com:street1>20 S. WACKER DR.</com:street1>
        <com:city>CHICAGO</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60606</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>3129301000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SIEGEL HOWARD J</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>20000</noOfUnitsSold>
      <aggregateMarketValue>5113400.00</aggregateMarketValue>
      <noOfUnitsOutstanding>360354174</noOfUnitsOutstanding>
      <approxSaleDate>03/12/2025</approxSaleDate>
      <securitiesExchangeName>nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/29/2016</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>342</amountOfSecuritiesAcquired>
      <paymentDate>06/29/2016</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/25/2015</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1064</amountOfSecuritiesAcquired>
      <paymentDate>06/25/2015</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>08/25/2014</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>793</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2014</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/25/2014</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1415</amountOfSecuritiesAcquired>
      <paymentDate>06/25/2014</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/25/2013</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>982</amountOfSecuritiesAcquired>
      <paymentDate>06/25/2013</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/25/2012</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1870</amountOfSecuritiesAcquired>
      <paymentDate>06/25/2012</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/27/2011</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1335</amountOfSecuritiesAcquired>
      <paymentDate>06/27/2011</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/25/2010</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1205</amountOfSecuritiesAcquired>
      <paymentDate>05/25/2010</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/26/2009</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1645</amountOfSecuritiesAcquired>
      <paymentDate>05/26/2009</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/27/2008</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1105</amountOfSecuritiesAcquired>
      <paymentDate>05/27/2008</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/27/2007</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>975</amountOfSecuritiesAcquired>
      <paymentDate>05/27/2007</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>08/25/2006</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>325</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2006</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/25/2006</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>705</amountOfSecuritiesAcquired>
      <paymentDate>05/26/2006</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/05/2006</acquiredDate>
      <natureOfAcquisitionTransaction>Stock grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>915</amountOfSecuritiesAcquired>
      <paymentDate>05/05/2006</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/29/2001</acquiredDate>
      <natureOfAcquisitionTransaction>Initial Shares</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CME</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5324</amountOfSecuritiesAcquired>
      <paymentDate>06/29/2001</paymentDate>
      <natureOfPayment>Stock Grant</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>shares are being sold from HOWARD J SIEGEL REVOCABLE TRU U/A 6/12/12 FBO HOWARD J SIEGEL </remarks>
    <noticeSignature>
      <noticeDate>03/12/2025</noticeDate>
      <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Howard SIEGEL </signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
