X0306 4 2017-11-30 0 0001560241 G1 Therapeutics, Inc. GTHX 0001145929 SHAFFER CHRISTY L C/O G1 THERAPEUTICS, INC. 79 T.W. ALEXANDER DRIVE RESEARCH TRIANGLE PARK NC 27709 1 0 0 0 Common Stock 2017-11-30 4 J 0 99513 0.00 D 0 I By L2 Ventures, LLC Common Stock 2017-11-30 4 J 0 995 0.00 A 995 I By Hatteras Venture Advisors V, LLC In-kind distribution from L2 Ventures, LLC to its members, without consideration. The Reporting Person is one of the general partners of Hatteras Venture Advisors V, LLC, which is the general partner of L2 Ventures, LLC ("L2 Ventures"). L2 Ventures is the record holder of the securities, and the Reporting Person may be deemed to share voting and dispositive power over the securities held by L2 Ventures. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of her pecuniary interest therein. In-kind distribution from L2 Ventures, LLC to its members, including Hatteras Venture Advisors V, LLC, without consideration. The Reporting Person is one of the general partners of Hatteras Venture Advisors V, LLC, which is the record holder of the securities, and the Reporting Person may be deemed to share voting and dispositive power over the securities held by Hatteras Venture Advisors V, LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of her pecuniary interest therein. /s/ Megan Gates, attorney-in-fact 2017-12-04