X0303 4 2010-11-01 0 0001145404 CORNERSTONE THERAPEUTICS INC CRTX 0001304113 Powell Andrew Kenneth William C/O CORNERSTONE THERAPEUTICS 1255 CRESCENT GREEN DRIVE, SUITE 250 CARY NC 27518 0 1 0 0 EVP, General Counsel Common Stock 2010-11-01 4 S 0 7900 6.28 D 104100 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 19, 2010. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $6.24 to $6.37, inclusive. The reporting person undertakes to provide to Cornerstone Therapeutics Inc., any security holder of Cornerstone Therapeutics Inc., or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote to this Form 4. /s/ Andrew K. W. Powell 2010-11-02