X0202 4 2006-06-25 0 0001145404 CRITICAL THERAPEUTICS INC CRTX 0001291768 Newman Walter C/O CRITICAL THERAPEUTICS 60 WESTVIEW STREET LEXINGTON MA 02421 0 1 0 0 CSO/SVP Research & Development Option to Purchase Common Stock (Right to Buy) 3.80 2006-06-25 4 A 0 50000 A 2016-06-24 Common Stock 50000 50000 D This option vests as to 25% of the shares subject thereto on the first anniversary of the grant date, and vests as to the remaining shares in 36 approximately equal monthly installments beginning at the end of the one-month period following the first anniversary of the grant date until the fourth anniversary of the grant date. Not applicable. /s/ Walter Newman 2006-06-27