X0202 4 2005-11-30 0 0001145404 CRITICAL THERAPEUTICS INC CRTX 0001210905 RUBIN PAUL D C/O CRITICAL THERAPEUTICS, INC. 60 WESTVIEW STREET LEXINGTON MA 02421 1 1 0 0 President and CEO Common Stock 9866 I Held by Daughter Common Stock 2005-11-30 4 S 0 200 6.34 D 66170 D Common Stock 2005-11-30 4 S 0 502 6.35 D 65668 D Common Stock 2005-11-30 4 S 0 598 6.36 D 65070 D Common Stock 2005-11-30 4 S 0 200 6.37 D 64870 D Common Stock 2005-11-30 4 S 0 54 6.38 D 64816 D Common Stock 2005-11-30 4 S 0 4 6.39 D 64812 D Common Stock 2005-11-30 4 S 0 1000 6.40 D 63812 D Common Stock 2005-11-30 4 S 0 900 6.45 D 62912 D Common Stock 2005-11-30 4 S 0 1042 6.50 D 61870 D Common Stock 2005-11-30 4 S 0 500 6.51 D 61370 D Represents shares held by the daughter of the reporting person. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. This report should not be deemed an admission that the reporting person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 9, 2005. /s/ Scott B. Townsend, Attorney-in-Fact 2005-11-30